Impulsivity as a mediating mechanism between early-life adversity and addiction: Theoretical comment on Lovic et al. (2011).
Bibliographic record
Abstract
Early-life adversity, impulsivity, and dopaminergic function have all been implicated in adult drug addiction. The article by Lovic, Keen, Fletcher, and Fleming in this issue further elucidates this relationship by demonstrating that early-life adversity can increase impulsivity and decrease behavioral flexibility in adulthood. Recent literature suggests that these results are likely due to structural and functional changes in regions such as the orbitofrontal cortex (OFC) and nucleus accumbens (NAc), as well as altered dopamine activity. Impulsivity and behavioral inflexibility can increase susceptibility to addiction, and in turn, chronic substance abuse can impair the neurocircuitry underlying behavioral inhibition. Thus, early-life adversity may act as an entry point into a feed-forward spiral of impulsivity and addiction via the dysfunction of regions such as the OFC, NAc, and mesolimbic dopamine. (PsycINFO Database Record (c) 2011 APA, all rights reserved).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.005 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".