Expression of COX-1 and COX-2 mRNAs in atherosclerotic plaques
Bibliographic record
Abstract
Inflammation is a characteristic of atherosclerotic plaques. Prostaglandins are inflammatory mediators whose production is controlled by cyclooxygenase (COX). There are two isoforms: COX-1 and COX-2. COX-1 is relatively stable while COX-2 is induced in inflammatory states. In order to evaluate their possible contribution to atherosclerotic plaque inflammation, we measured their relative levels in postmortem plaque and adjacent normal arterial tissue. Eleven pairs of atherosclerotic plaque and adjacent normal arterial tissue were obtained from postmortem specimens. Total RNA was extracted and relative levels of COX-1 and COX-2 determined by the technique of RT-PCR. COX-2 levels were 4.8-fold higher in plaque tissue than in normal artery. COX-1 levels were only 1.1-fold higher. There was no relationship between sex, age, postmortem delay or cause of death and COX-2 or COX-1 levels. COX-2 levels are sharply upregulated in atherosclerotic plaques, indicating that it may be a significant contributor to plaque inflammation. Accordingly, COX-2 inhibitors may reduce the degree of inflammation and protect against future cardiovascular events.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".