Induction of angiogenesis in the ??-amyloid peptide-injected rat hippocampus
Bibliographic record
Abstract
Angiogenesis, the formation of new capillary blood vessels, has been studied following the stereotaxic injection of beta-amyloid peptide (Abeta1-42) into rat hippocampus. Immunohistochemical analysis for laminin showed that neovascularization was only slightly increased, relative to control, in the hippocampus 1 day post-Abeta1-42 injection. However, 7 days following peptide injection neovascularization was markedly up-regulated (by 2.2-fold) compared to control. Immunoreactivity for the angiogenic stimulatory agent vascular endothelial growth factor (VEGF) was also significantly increased in the hippocampus 7 days after Abeta1-42 injection. Double immunofluorescence staining demonstrated that the increased level of VEGF immunoreactivity was localized to both astrocytes and microglia, suggesting inflammatory responses contributed to angiogenesis. The findings of beta-amyloid stimulated angiogenesis and the involvement of peptide-induced inflammatory processes may have relevance to the pathology of Alzheimer's disease.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".