Multiphoton Microscopy of Healthy and Aneurismal Human Ascending Aorta
Bibliographic record
Abstract
The ascending aorta (AA) is the largest artery in the human body. It is responsible for transporting blood between the heart and the rest of the body. The structure of the AA allows it to withstand the resulting blood flow forces. This unique structure is due primarily to the proteins collagen and elastin. Collagen accounts for the strength of the aorta while the mechanical properties of the tissue, under healthy physiological conditions, is dominated by the elastin. Aneurysms are the primary disease associated with the AA, where the diameter of the vessel increases over 1.5 times its original size. Aneurysms can result in severe blood flow disturbances or rupture of the AA and almost always require surgical intervention. The development of an aneurysm is due to a weakening of the aortic wall, specifically the degradation of the structural proteins. This study examines the changes that occur to collagen and elastin in the ascending aorta with aneurysms using multiphoton microscopy. Specifically, the orientation of collagen fibers and the morphology of the fenestrations in the elastic lamina are compared between healthy and dilated human ascending aortas.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".