The level of matrix metalloproteinase‐2 in donor plasma strongly correlates with post‐transfusion recovery of stored platelet concentrates
Bibliographic record
Abstract
BACKGROUND AND OBJECTIVE: A simple test accurately predicting post-transfusion recovery of stored platelet concentrates (PCs) is needed. MATERIALS AND METHODS: Matrix metalloproteinase-2 (MMP-2) was determined in fresh-frozen plasma of normal donors using enzyme-linked immunosorbent assay (ELISA)-based assay. Post-transfusion recovery of human PCs was determined in rabbits with an inhibited reticuloendothelial system by flow cytometry. RESULTS: We demonstrated a strong positive (r = 0.91) and highly significant (P = 0.0015) correlation between the concentration of MMP-2 in plasma of normal donors and post-transfusion recovery of PCs stored for 5 days at 22 degrees C under standard blood banking conditions. A higher level of donor plasma MMP-2 is associated with improved recovery of transfused platelets. CONCLUSION: These observations suggest that pre-transfusion MMP-2 assay of donor's plasma may be a predictor of post-transfusion recovery of PCs. However, the usefulness of this assay should be elucidated in clinical transfusion settings.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".