Predicting the target genes of intronic microRNAs using large-scale gene expression data
Bibliographic record
Abstract
Current microRNA target prediction techniques provide long lists of putative miRNA-target interactions, many of which are false positives. The goal of this paper is to identify functional targets in these lists based on biological evidence obtained from the expression profiles of the host genes of intronic miRNAs and those of their targets. We propose a scoring strategy for each interaction based on the combinatorial effect of miRNAs. In particular, the change in expression level of a target gene is expressed in terms of a linear combination of the host gene data which are used as surrogates for expression data of the intronic miRNAs. The parameters of this linear model give an estimate of the contribution of each intronic miRNA in down-regulating the target gene. The experimental results show that our prediction technique is able to detect several functional interactions. In addition, the analysis of mRNA microarrays after intronic miRNA transfection confirms that significantly down-regulated genes are among targets detected by our technique.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".