Plasma Kallikrein Activity and Prekallikrein Levels during Endotoxin Shock in Dogs
Bibliographic record
Abstract
Endotoxin shock (ES) was induced in Labrador retriever dogs by infusion of a lethal dose of Escherichia coli endotoxin. Spontaneous plasma kallikrein activity and prekallikrein levels were determined during subsequent stages of the shock both by an esterolytic assay (BAEe) and a new amidolytic assay utilizing a chromogenic tripeptide derivative (Chromozym PK, Prntapharm AG, Basel Switzerland). During the late stages of shock characterized by a substantial decline of blood pressure, plasma prekallikrein levels determined by the amidolytic assay were considerably reduced. In this phase of the shock both the esterolytic and the amidolytic assays revealed a significant elevation of spontaneous activity. Plasma prekallikrein determined by the esterolytic assay was found to be elevated vs. control values for the whole duration of ES. The findings made seem to associate activation of the plasma kallikrein-kinin system to the circulatory collapse of endotoxin shock in dogs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".