Deviant p300 amplitude development in males is associated with paternal externalizing psychopathology.
Bibliographic record
Abstract
Boys at risk for alcoholism show deviant P300 amplitude development. Genetic influences on P300, however, are related to a range of externalizing disorders. This study examined whether P300 development from adolescence to early adulthood differed between groups varying in severity of paternal externalizing. Parietal P300 was assessed during the "rotated heads" task on up to 3 times between the ages of 17 and 24 years. Participants were divided into 3 paternal externalizing groups: (a) severe (father has adult antisocial behavior), (b) intermediate (father has alcohol dependence but not a more severe disorder), and (c) low (father has no externalizing disorders or substance treatment and is not extreme in alcohol use). Mixed models were used to evaluate linear change in amplitude. P300 decreased with age. The severe-risk group had smaller P300 initially and changed less with time than did the low-risk group. The intermediate-risk group did not differ significantly from the low-risk group, but differed marginally from the severe-risk males. Externalizing and early-onset substance disorders in the sons were associated with smaller initial values of P300. Measures of deviant P300 development may be vulnerability markers for externalizing psychopathology.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".