Attenuation of Long-Term Depression in Human Striatum after Anterior Capsulotomy
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Bibliographic record
Abstract
Aberrant synaptic plasticity in corticostriatal circuits may be an underlying mechanism of anxiety disorders such as obsessive-compulsive disorder (OCD). We explored the effect of anterior capsulotomy in an OCD patient on long-term depression (LTD) in the striatum. Dual microelectrodes were used to record and stimulate in the region of the anterior limb of the internal capsule and ventral striatum. Single pulses were used to evoke field excitatory postsynaptic potentials (fEPSPs) and high-frequency stimulation (HFS) was used to induce LTD before and after the surgical procedure on the initial side. Whereas striatal fEPSPs underwent LTD in response to HFS before capsulotomy, there was an attenuation of LTD in response to the same stimulus after the procedure concomitant with the patient's report of a reduction in anxiety. Our observation of human striatal LTD attenuation concomitant with reduced anxiety following anterior capsulotomy suggests that reduction in synaptic plasticity is related to an acute improvement of OCD symptoms.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it