Attenuation of Long-Term Depression in Human Striatum after Anterior Capsulotomy
Bibliographic record
Abstract
Aberrant synaptic plasticity in corticostriatal circuits may be an underlying mechanism of anxiety disorders such as obsessive-compulsive disorder (OCD). We explored the effect of anterior capsulotomy in an OCD patient on long-term depression (LTD) in the striatum. Dual microelectrodes were used to record and stimulate in the region of the anterior limb of the internal capsule and ventral striatum. Single pulses were used to evoke field excitatory postsynaptic potentials (fEPSPs) and high-frequency stimulation (HFS) was used to induce LTD before and after the surgical procedure on the initial side. Whereas striatal fEPSPs underwent LTD in response to HFS before capsulotomy, there was an attenuation of LTD in response to the same stimulus after the procedure concomitant with the patient's report of a reduction in anxiety. Our observation of human striatal LTD attenuation concomitant with reduced anxiety following anterior capsulotomy suggests that reduction in synaptic plasticity is related to an acute improvement of OCD symptoms.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".