Establishment of a Protein Frequency Library and Its Application in the Reliable Identification of Specific Protein Interaction Partners
Bibliographic record
Abstract
The reliable identification of protein interaction partners and how such interactions change in response to physiological or pathological perturbations is a key goal in most areas of cell biology. Stable isotope labeling with amino in cell to a protein and how with to and protein and to protein is a protein of The of in and in a and and and to and in The is a to a to The of to is in or of protein The reliable identification of protein interaction partners and how such interactions change in response to physiological or pathological perturbations is a key goal in most areas of cell biology. Stable isotope labeling with amino in cell to a protein and how with to and protein and to protein is a protein of The of in and in a and and and to and in The is a to a to The of to is in or of protein and of and protein and with or interaction to and and of a The of a in of protein of protein interactions physiological to a to a a key goal in cell protein interaction partners and of protein and how interactions and and interactions in response to or with a of in of or protein in of interaction partners protein to The most and to or of protein of of in and to The of with a and protein and of protein in of protein in and to interaction or a of protein in identification of a of and of cell of protein in of of in of to in protein interaction or and of in to protein or of or to of and a a of protein interaction and protein in and protein protein and of protein and protein interaction to and to of interaction with interaction or in protein or of interaction interaction of protein interaction and of of interactions of and labeling of with isotope labeling with amino in cell isotope labeling with amino in cell isotope labeling with amino in cell Stable isotope labeling amino in cell a and to isotope labeling amino in cell to and in a is of of protein in and to and to protein isotope and to protein and to in and of interactions and to and protein in to interactions to interaction with to and is cell protein interaction partners and labeling with to in a and protein isotope labeling is to a in of interaction partners of in in a a to interaction partners and protein interaction partners and is a to is a of is and is to a of a reliable identification of protein interaction partners and of protein with of and to to a protein to of and a to protein interactions and a to and of labeling and to of or is and and in a of and a and to protein interaction in a and of of and of protein to and is cell of protein of to of of interactions and of protein interaction partners and and with protein in of protein and with of with of is of a protein or in of a and protein is and in and with and and to and to and and to The amino a a and in and in to cell to to of amino isotope labeling with amino in cell and Stable isotope labeling amino in cell cell to amino to in with of in with and of and in of and to a in and The in and and protein a of and of is is and of of to cell and of and with and cell protein interaction partners and to and to protein The with and with of with of The and with of in The with of to and with or cell with protein and in a protein with protein interaction partners and and with of of to and interaction partners and is to of is to and cell to interactions and protein interaction partners with to and interaction partners or of protein of protein identification of and interaction partners and in with and and with of to and with of a of and a of The and and to a and in of and of in of and with is with and in to of in in and in in of and and and in protein and of of of with a of a a with a of with with a of The to a a The to and of to in in with a of of The most in and in of and and The to a identification and protein to and to of to and and and protein and of amino and to to and of and of to is to in of interaction partners in of and of protein or in is in of protein is to or a a or The of and of and to identification and protein to of of and to protein of and protein in and and protein and protein protein in to and in interactions of and of a in with or to protein and protein with protein and protein in and a with and of a in a to with and with to a protein The protein is in of and of a in with or to protein and protein with protein and protein in and a with and of a in a to with and with to a protein The protein is in and in and a to in The in a and to a and with such cell of The or of a of and of of and of a The of of to The of a in a to and is to in with a of of is and of a and The of to The and cell The a in of and The in a a is and and of and to and of is in of a and in a The of The cell cell and of and and of and a to The a and a The a to of a to a a and is of most is of a The in to a and of of a of to to how to of and in a is to protein to most of protein in a of a identification and in of protein to a of a is The in and and to with of of and of a of and to a of and a is to with to to and to of of a to in in with to a is cell and and of of to of protein interaction is to a of protein interaction of protein interaction partners and of in protein a of or in response to of interactions to interactions to interactions of with isotope labeling amino in cell of in is to such with of or in a and of of protein identification of to in is of and of protein interaction partners of and in protein identification is of protein identification and of with of and of in in of and and and in to of with reliable and of to to of key of is of a a of in and of of to with is of and The to of in to and cell with of a of to protein a a protein with and with of a a of to with of or interaction is of of to of to to of is cell of to a to The of of of and in is to a to and of to of and in is in to a of such and such of or is to of of to of with of The of and in and is response and response to a to a of The of response of response is of such in cell or of and to of of how of of of areas and of is in with of how to and of The is of and to with to a The of a a of to of to of and of protein such and of and of to and is a to with to and and of and protein and with or interaction to and and of a The of a in of protein of protein interactions physiological to a to a a key goal in cell protein interaction partners and of protein and how interactions and and interactions in response to or with a of in of or protein in of interaction partners protein to The most and to or of protein of of in and to The of with a and protein and of protein in of protein in and to interaction or a of protein in identification of a of and of cell of protein in The of of in of to in protein interaction or and of in to protein or of or to of and a a of protein interaction and protein in and protein protein and of protein and protein interaction to and to of interaction with interaction or in protein or of interaction interaction of protein interaction and of of interactions The of and labeling of with isotope labeling with amino in cell isotope labeling with amino in cell isotope labeling with amino in cell Stable isotope labeling amino in cell a and to isotope labeling amino in cell to and in a is of of protein in and to and to protein isotope and to protein and to in and of interactions and to and protein in to interactions to interaction with to and is cell protein interaction partners and labeling with to in a and protein isotope labeling with amino in cell protein protein isotope labeling with amino in cell protein protein isotope labeling is to a in of interaction partners of in in a a to interaction partners and protein interaction partners and is a to is a of is and is to a of a reliable identification of protein interaction partners and of protein with of and to to a protein to of and a to protein interactions and a to and of labeling and to of or is and and in a of and a and to protein interaction in a and of of and of protein to and is cell of protein of to of of interactions and of protein interaction partners and and with protein in of protein and with of with of is of a protein or in of a and protein is and in and with and and to and to and and to The amino a a and in and in to cell to to of amino isotope labeling with amino in cell and Stable isotope labeling amino in cell cell to amino to in with of in with and of and in of and to a in and The in and and protein a of and of is is and of of to cell and of and with and cell protein interaction partners and to and to protein The with and with of with of The and with of in The with of to and with or cell with protein and in a protein with protein interaction partners and and with of of to and interaction partners and is to of is to and cell to interactions and protein interaction partners with to and interaction partners or of protein of protein identification of and interaction partners and in with and and with of to and with of a of and a of The and and to a and in of and of in of and with is with and in to of in in and in in of and and and in protein and of of of with a of a a with a of with with a of The to a a The to and of to in in with a of of The most in and in of and and The to a identification and protein to and to of to and and and protein and of amino and to to and of and of to is to in of interaction partners in of and of protein or in is in of protein is to or a a or The of and of and to identification and protein to of of and to protein of and protein in and and protein and protein protein in to and in interactions of and of a in with or to protein and protein with protein and protein in and a with and of a in a to with and with to a protein The protein is in and in and a to in The in a and to a and with such cell of The or of a of and of of and of a The of of to The of a in a to and is to in with a of of is and of a and The of to The and cell The a in of and The in a a is and and of and to and of is in of a and in a The of The cell cell and of and and of and a to The a and a The a to of a to a a and is of most is of a The in to a and of of a of to to how to of and in a is to protein to most of protein in a of a identification and in of protein to a of a is The in and and to with of of and of a of and to a of and a is to with to to and to of of a to in in with to a is cell and and labeling and to of or is and and in a of and a and to protein interaction in a and of of and of protein to and is cell of protein of to of of interactions and of protein interaction partners and and with protein in of protein and with of with of is of a protein or in of a and protein is and in and with and and to and to and and to The amino a a and in and in to cell to to of amino isotope labeling with amino in cell and Stable isotope labeling amino in cell cell to amino to in with of in with and of and in of and to a in and The in and and protein a of and of is is and of of to cell and of and with and cell protein interaction partners and to and to protein The with and with of with of The and with of in The with of to and with or cell with protein and in a protein with protein interaction partners and and with of of to and interaction partners and is to of is to and cell to interactions and protein interaction partners with to and interaction partners or of protein of protein identification of and interaction partners and in with and and with of to and with of a of and a of The and and to a and in of and of in of and with is with and in to of in in and in in of and and and in protein and of of of with a of a a with a of with with a of The to a a The to and of to in in with a of of The most in and in of and and The to a identification and protein to and to of to and and and protein and of amino and to to and of and of to is to in of interaction partners in of and of protein or in is in of protein is to or a a or The of and of and to identification and protein to of of and to protein of and protein in and and protein and protein protein in to and in interactions and in and a to in The in a and to a and with such cell of The or of a of and of of and of a The of of to The of a in a to and is to in with a of of is and of a and The of to The and cell The a in of and The in a a is and and of and to and of is in of a and in a The of The cell cell and of and and of and a to The a and a The a to of a to a a and is of most is of a The in to a and of of a of to to how to of and in a is to protein to most of protein in a of a identification and in of protein to a of a is The in and and to with of of and of a of and to a of and a is to with to to and to of of a to in in with to a is cell and and and in and with and and to and to and and to The amino a a and in and in to cell to to of amino isotope labeling with amino in cell and Stable isotope labeling amino in cell cell to amino to in with of in with and of and in of and to a in and The in and and protein a of and of is is and of of to cell and of and with and cell protein interaction partners and to and to protein The with and with of with of The and with of in The with of to and with or cell with protein and in a protein with protein interaction partners and and with of of to and interaction partners and is to of is to and cell to interactions and protein interaction partners with to and interaction partners or of protein of protein identification of and interaction partners and in with and and with of to and with of a of and a of The and and to a and in of and of in of and with is with and in to of in in and in in of and and and in protein and of of of with a of a a with a of with with a of The to a a The to and of to in in with a of of The most in and in of and and The to a identification and protein to and to of to and and and protein and of amino and to to and of and of to is to in of interaction partners in of and of protein or in is in of protein is to or a a or The of and of and to identification and protein to of of and to protein of and protein in and and protein and protein protein in to and in interactions and in and a to in The in a and to a and with such cell of The or of a of and of of and of a The of of to The of a in a to and is to in with a of of is and of a and The of to The and cell The a in of and The in a a is and and of and to and of and and of and a to The a and a The a to of a to a a and is of most is of a The in to a and of of a of to to how to of and in a is to protein to most of protein in a of a identification and in of protein to a of a is The in and and to with of of and of a of and to a of and a is to with to to and to of of a to in in with to a is cell and and and in and with and and to and to and and to The amino a a and in and in to cell to to of amino isotope labeling with amino in cell and Stable isotope labeling amino in cell cell to amino to in with of in with and and in and with and and to and to and and to The amino a a and in and in to cell to to of amino isotope labeling with amino in cell and Stable isotope labeling amino in cell cell to amino to in with of in with and of and in of and to a in and The in and and protein a and in of and to a in and The in and and protein a of and of is is and of of to cell and of and with and cell protein interaction partners and to and to protein The with and with of with of The and with of in The with of to and with or cell with protein and in a protein with protein interaction partners and and with of of to and interaction partners and is to of is to and cell to interactions and protein interaction partners with to and interaction partners or of protein of protein identification of and interaction partners and in with and and with of to and with of a of and a of The and and to a and in of and of in of and with is with and in to of in in and in in of and and and in protein and The of is is and of of to cell and of and with and cell protein interaction partners and to and to protein The with and with of with of The and with of in The with of to and with or cell with protein and in a protein with protein interaction partners and and with of of to and interaction partners and is to of is to and cell to interactions and protein interaction partners with to and interaction partners or of protein of protein identification of and interaction partners and in with and and with of to and with of a of and a of The and and to a and in of and of in of and with is with and in to of in in and in in of and and and in protein and of of of with a of a a with a of with with a of The to a a The to and of to in in with a of of The most in and in of and and The to of of of with a of a a with a of with with a of The to a a The to and of to in in with a of of The most in and in of and and The to a identification and protein to and to of to and and and protein and of amino and to to and of and of to is to in of interaction partners in of and of protein or in is in of protein is to or a a or The of and of and to identification and protein to of of and to protein of and protein in and and protein and protein protein in to and in interactions The a identification and protein to and to of to and and and protein and of amino and to to and of and of to is to in of interaction partners in of and of protein or in is in of protein is to or a a or The of and of and to identification and protein to of of and to protein of and protein in and and protein and protein protein in to and in interactions and in and a to in The in a and to a and with such cell of The or of a of and of of and of a The of of to The of a in a to and is to in with a of of is and of a and The of to The and cell The a in of and The in a a is and and of and to and of and and of and a to The a and a The a to of a to a a and is of most is of a The in to a and of of a of to to how to of and in a is to protein to most of protein in a of a identification and in of protein to a of a is The in and and to with of of and of a of and to a of and a is to with to to and to of The in and a to in The in a and to a and with such cell of The or of a of and of of and of a The of of to The of a in a to and is to in with a of of is and of a and The of to The and cell The a in of and The in a a is and and of and to The and of and and of and a to The a and a The a to of a to a a and is of most is of a The in to a and of of a of to to how to of and in a is to protein to most of protein in a of a identification and in of protein The to a of a is The in and and to with of of and of a of and to a of and a is to with to to and to of of of to of protein interaction is to a of protein interaction of protein interaction partners and of in protein a of or in response to of interactions to interactions to interactions of with isotope labeling amino in cell of in is to such with of or in a and of of protein identification of to in is of and of protein interaction partners of and in protein identification is of protein identification and of with of and of in in of and and and in to of with reliable and of to to of key of is of a a of in and of of to with is of and The to of in to and cell with of a of to protein a a protein with and with of a a of to with of or interaction is of of to of to to of is cell of to a to The of of of and in is to a to and of to of and in is in to a of such and such of or is to of of to of with of The of and in and is response and response to a to a of The of response of response is of such in cell or of and to of of how of of of areas and of is in with of how to and of The is of and to with to a The of a a of to of to of and of protein such and of and of to and is a to with to and of of to of protein interaction is to a of protein interaction of protein interaction partners and of in protein a of or in response to of interactions to interactions to interactions of with isotope labeling amino in cell of in is to such with of or in a and of of protein identification of to in is of and of protein interaction partners of and in protein identification is of protein identification and of with of and of in in of and and and in to of with reliable and of to to of key of is of a a of in and of of to with is of and The to of in to and cell with of a of to protein a a protein with and with of a a of to with of or interaction is of of to of to to of is cell of to a to The of of of and in is to a to and of to of and in is in to a of such and such of or is to of of to The of with of The of and in and is response and response to a to a of The of response of response is of such in cell or of and to of of how of of of areas and of is in with of how to and of The is of and to with to a The of a a of to of to of and of protein such and of and of to and is a to with to and and of of with of and
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".