Nécrolyse épidermique toxique induite par la carbamazépine chez une Cambodgienne
Bibliographic record
Abstract
La carbamazepine (CBZ) est un anticonvulsivant souvent utilise dans le traitement de l’epilepsie ainsi que pour plusieurs autres problemes de sante. Recemment, la FDA (US Food and Drug Administration) ainsi que Sante Canada ont emis un avis mentionnant qu’il y a un risque accru de reactions cutanees graves, comprenant le syndrome de Stevens-Johnson (SSJ) et la necrolyse epidermique toxique (NET), lorsque la CBZ est utilisee chez les personnes d’origine asiatique, particulierement chez les descendants Chinois Hans1,2. La presence de l’allele HLA-B*1502 («human leucocyte antigen» B*-1502) chez cette population a ete fortement associee au risque de developper ce type de reaction. Le cas presente ici est celui d’une femme d’origine cambodgienne ayant developpe une NET induite par la CBZ.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.005 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".