Clearance of Cytomegalovirus Viremia after Initiation of Highly Active Antiretroviral Therapy
Bibliographic record
Abstract
In a recent report, O'Sullivan et al. [1] showed that immune reconstitution secondary to initiation of highly active antiretroviral therapy (HAART) in 23 human immunodeficiency virus (HIV)-infected subjects with low CD4 T cell counts (median, 35 cells/mm3) resulted in a progressive decline in cytomegalovirus (CMV) DNAemia (as measured by the Digene [Beltsville, MD] hybrid capture system) in the absence of specific anti-CMV therapy. In their study, the CMV DNA load was determined after a median of ∼1, 3, and 12 months of therapy, with a significant reduction in the CMV load noted after time point 2. To contribute to these findings, we report results of a detailed analysis of CMV viremia (conventional cell culture), antigenemia (pp65 antigen, CINApool; Biosoft, Varilhes, France), and DNAemia by means of a quantitative polymerase chain reaction (PCR) on plasma and leukocytes (Amplicor Monitor CMV test; Roche Diagnostics, Branchburg, NJ) in an antiretroviral-naive HIV-infected subject in whom HAART was initiated.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.016 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.012 | 0.008 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".