A new cell-based FE model for the mechanics of embryonic epithelia
Why this work is in the frame
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Bibliographic record
Abstract
In order to overcome a significant stiffening artefact associated with current finite element (FE) models for the mechanics of embryonic epithelia, two new FE formulations were developed. Cell-cell interfacial tensions gamma are represented by constant-force rod elements as in previous models. However, the viscosity of the cytoplasm with its embedded organelles and filament networks is modeled using viscous triangular elements, it is modeled using either radial and circumferential dashpots or an orthogonal dashpot system rather than the viscous triangular elements typical of previous two-dimensional FE models. The models are tested against tissue (epithelium) stretching because it gives rise to significant changes in cell shape and against cell sorting because it involves high rates of cell rearrangement. The orthogonal dashpot system is found to capture cell size and shape effects well, give the model cells characteristics that are consistent with those of real cells, provide high computational efficiency and hold promise for future three-dimensional analyses.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it