Sci‐Sat AM (1) General‐06: Theoretical estimation of dose volume constraints and their impact on DVH selection
Bibliographic record
Abstract
Dose‐volume constraints are essential for treatment planning optimization using physical objective functions. A theoretical approach to the problem of choosing dose‐volume constraints based on the reverse normal tissue complication probability (NTCP) mapping into dose‐volume space is developed. Dose‐volume histograms (DVHs) are randomly simulated and those resulting in clinically acceptable levels of complication, e.g. NTCP of 5±0.5%, are selected and averaged producing a mean DVH which is proven to result in the same level of NTCP. The points from the averaged DVH are proposed to serve as dose‐volume constraints for treatment planning optimization using physical objective functions. The population based Critical Volume and the Lyman NTCP models with parameter sets taken from literature were used for the NTCP estimation. Constraint points for 16 organs are calculated. These dose‐volume constraints are not unique and depend on the range in which the maximum dose to the organ at risk, Dmax, is allowed to vary. It is theoretically proven that the radiation treatment optimization based on physical objective functions can sufficiently well restrict the dose to the organs at risk resulting in sufficiently low NTCP values through the employment of several appropriate dose‐volume constraints. At the same time, the pure physical approach to optimization is self‐restrictive due to the pre‐assignment of acceptable NTCP levels thus excluding possible better solutions to the problem.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.142 | 0.033 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".