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Record W2059494882 · doi:10.1177/1715163513481569

Cardiovascular risk

2013· article· fr· W2059494882 on OpenAlex
Nadia Pawlosky

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
venuePublished in a venue whose home country is Canada.

Bibliographic record

VenueCanadian Pharmacists Journal / Revue des Pharmaciens du Canada · 2013
Typearticle
Languagefr
FieldMedicine
TopicInflammatory mediators and NSAID effects
Canadian institutionsRoyal Jubilee HospitalIsland Health
Fundersnot available
KeywordsMedicineRofecoxibOver-the-counterAdverse effectNonsteroidalIncidence (geometry)DiseaseInternal medicineHeart failureIntensive care medicinePharmacologyCyclooxygenase

Abstract

fetched live from OpenAlex

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed medications purchased over the counter to treat acute and chronic pain and inflammation associated with a range of medical conditions.1 It is estimated that NSAIDs are prescribed to about 25% of Canadians for short-term use, but overall use is likely much higher with over-the-counter availability.2 Like any medication, the benefits of NSAIDs should be considered in tandem with the potential adverse effects. Side effects range from the mild and common to the severe and infrequent: dyspepsia, gastric or duodenal ulceration, sodium retention and subsequent hypertension, as well as increased incidence of cardiovascular (CV) adverse events. It was the withdrawal of rofecoxib from the market that brought to light the CV risk of NSAIDs and, in fact, a black-box warning now exists in NSAID product monographs, advising caution when prescribing to patients with ischemic heart disease, cerebrovascular disease and/or congestive heart failure.3 This article focuses on the CV effects associated with NSAID use by reviewing the recent literature on this topic.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Science and technology studies, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.535
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0020.001
Scholarly communication0.0000.001
Open science0.0010.000
Research integrity0.0000.003
Insufficient payload (model declined to judge)0.0130.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.227
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it