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Record W2059690361 · doi:10.1159/000179798

Autoradiographic Localization of 1,25-Dihydroxyvitamin D <sub>3</sub> in Rat Placenta and Yolk Sac

2008· article· en· W2059690361 on OpenAlex
Walter E. Stumpf, M. Sar, Roberto Narbaitz, Stella Huang, H. F. DeLuca

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueHormone Research · 2008
Typearticle
Languageen
FieldMedicine
TopicVitamin D Research Studies
Canadian institutionsUniversity of Ottawa
Fundersnot available
KeywordsYolk sacPlacentaAmnionFetusVitamin D and neurologyVitaminEndocrinologyInternal medicineChemistryNuclear receptorReceptorAndrologyPregnancyBiologyCell biologyEmbryoBiochemistryMedicine

Abstract

fetched live from OpenAlex

After injection of 3H-1,25-(OH)-vitamin D&lt;sub&gt;3&lt;/sub&gt; into rats on days 18 and 20 of pregnancy, autoradiograms of placenta and fetal membranes show nuclear concentration of radioactivity in certain cells. This nuclear concentration is abolished when unlabeled 1,25-(OH)&lt;sub&gt;2&lt;/sub&gt;-vitamin D&lt;sub&gt;3&lt;/sub&gt;, but not 25-(OH)-vitamin D&lt;sub&gt;3&lt;/sub&gt;, is injected prior to the labeled hormone. Nuclear labeling is observed in epithelial cells of visceral yolk sac and amnion, and in certain trophoblasts in basalis and labyrinth. The results suggest the presence of a specific receptorlike binding for 1,25-(OH)&lt;sub&gt;2&lt;/sub&gt;-vitamin D&lt;sub&gt;3&lt;/sub&gt; and thus involvement of the target cells in calcium regulatory mechanisms during development.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.479
Threshold uncertainty score0.656

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.002
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.050
GPT teacher head0.333
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it