Low frequency-modulated high frequency oscillations in seizure-like events recorded from in-vivo MeCP2-deficient mice
Bibliographic record
Abstract
Rett syndrome is a neurodevelopmental condition caused by mutations in the gene encoding methyl CpG-binding protein 2 (MeCP2). Seizures are often associated with Rett syndrome and can be observed in intracranial electroencephalogram (iEEG) recordings. To date most studies have focused on the low frequencies oscillations (LFOs), however recent findings in epilepsy studies link high frequency oscillations (HFOs) with epileptogenesis. In this study, we examine the presence of HFOs in the male and female MeCP2-deficient mouse models of Rett syndrome and their interaction with the LFOs present during seizure-like events (SLEs). Our findings indicate that HFOs (200-600 Hz) are present during the SLEs and in addition, we reveal strong phase-amplitude coupling between LFOs (6-10 Hz) and HFOs (200-600 Hz) during female SLEs in the MeCP2-deficient mouse model.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".