Relation of c-AMP to Relaxation of Pulmonary Artery
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Bibliographic record
Abstract
We tested the hypothesis that an increase in c-AMP was necessary or sufficient for relaxation of rabbit pulmonary artery. Isoproterenol (INA) partially relaxed serotonin (5-HT) induced contractions. Theophylline (TH) alone relaxed contraction more effectively, but after TH, INA produced no greater relaxation. At the height of relaxation (2 min), c-AMP was not increased, but after 5 min the c-AMP was decreased and the artery was recontracted. c-AMP was increased after TH, and more when INA was given after TH. Noradrenaline contracted the arteries and increased c-AMP; both effects were prevented by phentolamine. A series of other relaxants (papaverine, nitroglycerine, D600, Ro-7-2956, diazoxide and dipyridamole) also failed to produce relaxations directly related to c-AMP levels. We concluded that c-AMP increase was not necessary or sufficient for relaxation in artery, and that in pulmonary artery phosphodiesterase activity played an important role in determining tissue levels of c-AMP.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it