Bibliographic record
Abstract
We tested the hypothesis that an increase in c-AMP was necessary or sufficient for relaxation of rabbit pulmonary artery. Isoproterenol (INA) partially relaxed serotonin (5-HT) induced contractions. Theophylline (TH) alone relaxed contraction more effectively, but after TH, INA produced no greater relaxation. At the height of relaxation (2 min), c-AMP was not increased, but after 5 min the c-AMP was decreased and the artery was recontracted. c-AMP was increased after TH, and more when INA was given after TH. Noradrenaline contracted the arteries and increased c-AMP; both effects were prevented by phentolamine. A series of other relaxants (papaverine, nitroglycerine, D600, Ro-7-2956, diazoxide and dipyridamole) also failed to produce relaxations directly related to c-AMP levels. We concluded that c-AMP increase was not necessary or sufficient for relaxation in artery, and that in pulmonary artery phosphodiesterase activity played an important role in determining tissue levels of c-AMP.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".