Endocannabinoids, their effect on GABA uptake in globus pallidus and relevance to Parkinson's disease
Bibliographic record
Abstract
Within the globus pallidus, CB1 cannabinoid receptors are localized presynaptically on GABAergic neurons. We focused on effect of endocannabinoids on GABA uptake in rat globus pallidus slices. Following incubation with 2‐arachidonyl glycerol (2‐AG) (1 and 3 μm), there was a 40%, and 30% increase, respectively, in [3H]‐GABA uptake (P < 0.05). When incubated with noladin ether (1 μm), an increase of 57% was observed (P < 0001). The effects of 2‐AG were reversed by the CB1 receptor antagonist AM 251 (1 μm), showing this mechanism is likely to be CB1 receptor‐mediated (P < 0.05). Neither anandamide (0.1–10 μm) nor synthetic cannabinoid WIN 55,212–2 (1–100 μm) had any effect. We suggest increased level of endocannabinoids, found in a Parkinson's disease model, might thus represent a compensatory mechanism. Acknowledgement: Supported by CEZ:J13/98:11600004.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".