Rifampin hypersensitivity in a two year-old child with successful rapid oral desensitization
Bibliographic record
Abstract
A two year, 10 month-old child was referred to a tertiary allergy clinic following an adverse reaction to rifampin. Her mother had isoniazid-resistant pulmonary tuberculosis. The child was born in Canada, was asymptomatic, had a normal chest x-ray and liver enzymes. Mantoux induration was 17 mm. The child was prescribed oral rifampin, 150 mg per day for 3 months. Thirty minutes after ingesting the fifth dose, she developed swelling of the lips, eyes and face; and a pruritic rash to the extremities and face. Anti-histamine was administered: the rash resolved over thirty minutes and facial swelling over 2-3 hours. There were no other IgEmediated symptoms. Rifampin was discontinued. Past history was negative for atopy, adverse drug reactions, and food allergies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.004 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".