Microangiopathic haemolytic anaemia and hyposplenism in angiosarcoma
Bibliographic record
Abstract
An 83-year-old man presented with an 18-month history of hyposplenic blood film features and progressive microangiopathic haemolytic anaemia for 6 months (top left). He had recently developed dyspnoea. Past history included melanoma and basal cell carcinoma. Bone marrow could not be aspirated. Touch preparations of a core biopsy specimen showed occasional large mononuclear cells (20–30 μm diameter) with variably vacuolated cytoplasm. The bone marrow was fibrotic and extensively infiltrated by spindle-shaped and polyhedral cells, focally forming vascular structures with red blood cells in them (bottom left), expressing CD31 (bottom right) and CD34, and lacking S100 and human herpesvirus 8, thus confirming the diagnosis of angiosarcoma. A computed tomography scan (top right) showed a normal sized spleen infiltrated by a multi-nodular conglomerate mass, haemoperitoneum adjacent to the liver and within the mesentery, and a cardiophrenic lymph node. The patient developed multi-organ failure and died within 2 weeks of his diagnosis. Thrombotic microangiopathy as a presenting feature of angiosarcoma is rarely described. Shearing of blood cells within the neoplastic blood vessels may contribute to this condition. Bone marrow involvement is rarely reported and usually represents disseminated disease.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".