Abstract B47: External Qi of Yan Xin Qigong induces cell cycle arrest and apoptosis in colon cancer cells through regulation of multiple signaling pathways
Bibliographic record
Abstract
Abstract The concept external Qi of Qigong refers to the technology and ability of “Qi deployment” therapy and health preservation of traditional Chinese medicine (TCM). External Qi therapy of TCM has long been one of the medical practices in China. Long-term clinical observations and ongoing studies have shown positive effects of external Qi of Yan Xin Qigong (YXQ-EQ) on patients of various types of cancer. The molecular and cellular mechanisms underlying YXQ-EQ's antitumor effects have recently begun to be addressed. In the present study we investigated YXQ-EQ's effects on the growth and apoptosis of human colon carcinoma HT-29 cells. We show that YXQ-EQ treatment reduced the viability and inhibited clonogenic growth of HT-29 cells. In agreement, YXQ-EQ induced cell cycle G1 arrest and apoptosis in HT-29 cells. YXQ-EQ induced apoptosis is accompanied by DNA fragmentation and cleavage of procaspase-3 and -9 and poly(ribose-ADP) polymerase. YXQ-EQ inhibited phosphorylation of Akt and GSK3β, decreased the levels of cyclin D1 and hyper-phosphorylated Rb, and repressed the expression of antiapoptic proteins Bcl-XL, XIAP, and survivin. Concomitantly, YXQ-EQ increased the expression of cyclin-dependent kinase inhibitor p21CIP1/WAF1. These findings suggest that YXQ-EQ may induce cell cycle arrest and apoptosis in colon cancer cells through regulation of multiple signaling pathways that play important roles in cell proliferation, survival and apoptosis. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B47.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".