Facile ligand-exchange with polyvinylpyrrolidone and subsequent silica coating of hydrophobic upconverting β-NaYF4:Yb3+/Er3+ nanoparticles
Why this work is in the frame
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Bibliographic record
Abstract
A facile ligand-exchange strategy with a water-soluble polymer, i.e. polyvinylpyrrolidone (PVP), to replace the surface passivating oleate ligands on the beta-NaYF(4) nanoparticle surface is reported. Highly monodisperse oleate-stabilized beta-NaYF(4) nanoparticles were synthesized and the oleates were exchanged with a commercially available PVP allowing the phase transfer of these nanoparticles. The exchanged nanoparticles are readily dispersible in water and other polar solvents. To show the effectiveness of the exchange reaction we used the affinity of the PVP chains to silica and coated the nanoparticles with a uniform, thin silica shell. The PVP exchanged and silica-coated nanoparticles show longer colloidal stability and no surfactant related problems as compared to the reverse microemulsion-based silica-coated nanoparticles, which show a high tendency to aggregate, when removed from the microemulsion. The optical properties of the ligand-exchanged nanoparticles dispersed in water were compared with that of the oleate-stabilized nanoparticles in organic solvents. A decrease in the upconversion emission intensity and a different relative ratio of the green and red upconverted light were observed for the particles dispersed in water after ligand-exchange. PVP is a highly biocompatible polymer and is reported to have a longer blood circulation time and very low accumulation in vital organs, two highly desired properties for in vivo studies. This ligand-exchange strategy opens a new pathway to study the use of beta-NaYF(4) for biological applications in vivo.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it