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Record W2063382533 · doi:10.1038/nature10933

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

2012· article· en· W2063382533 on OpenAlexaff
Sohrab P. Shah, Andrew Roth, Rodrigo Goya, Arusha Oloumi, Gavin Ha, Yongjun Zhao, Gulisa Turashvili, Jiarui Ding, Kane Tse, Gholamreza Haffari, Ali Bashashati, Leah Prentice, Jaswinder Khattra, Angela Burleigh, Damian Yap, Virginie Bernard, Andrew McPherson, Karey Shumansky, Anamaria Crisan, Ryan Giuliany, Alireza Heravi‐Moussavi, Jamie Rosner, Daniel Lai, İnanç Birol, Richard Varhol, Angela Tam, Noreen Dhalla, Thomas Zeng, Kevin Ma, Simon K. Chan, Malachi Griffith, Annie Moradian, Siwei Cheng, Gregg B. Morin, Peter H. Watson, Karen A. Gelmon, Stephen Chia, Suet‐Feung Chin, Christina Curtis, Oscar M. Rueda, Paul D.P. Pharoah, Sambasivarao Damaraju, John R. Mackey, Kelly Hoon, Timothy T. Harkins, Vasisht Tadigotla, Mahvash Sigaroudinia, Philippe Gascard, Thea D. Tlsty, J Costello, Irmtraud M. Meyer, Connie J. Eaves, Wyeth W. Wasserman, Steven J.M. Jones, David G. Huntsman, Martin Hirst, Carlos Caldas, Marco A. Marra, Samuel Aparício

Bibliographic record

VenueNature · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer Genomics and Diagnostics
Canadian institutionsUniversity of AlbertaSimon Fraser UniversityBC Cancer AgencyPacific Centre for Reproductive MedicineCanada's Michael Smith Genome Sciences CentreUniversity of British Columbia
FundersNational Institute of Environmental Health SciencesNational Institute for Health and Care ResearchNational Institute of General Medical SciencesCancer Research UK
KeywordsTriple-negative breast cancerSomatic evolution in cancerBiologySomatic cellBreast cancerCopy-number variationCancer researchGenotypeGeneAlleleDeep sequencingTranscriptomeGeneticsCancerGene expressionGenome

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.003
GPT teacher head0.222
Teacher spread0.219 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2,026
Published2012
Admission routes1
Has abstractno

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