Ethnic origin determines the impact of genetic variants in dopamine receptor gene () concerning essential hypertension
Bibliographic record
Abstract
The dopamine receptor type 1 (DRD1) has been implicated in the development of hypertension in humans as well as in animal models of spontaneous hypertension. We screened the entire coding and promoter region of the human DRD1 receptor for polymorphisms to analyze their association with hypertension. The allele frequencies of two common single-nucleotide polymorphisms, A-48G and G-94A were determined in 493 hypertensive patients and 209 normotensive controls. Allele frequencies did not differ for both polymorphisms between the two groups (-48 G-allele in hypertension = 0.37; -48 G-allele in normotension = 0.36; -94 A-allele in hypertension = 0.14; -94 A-allele in normotension = 0.10). Our findings in these Caucasian patients are in contrast to a recent Japanese study that revealed a significant association of the -48 G-allele with hypertension. Thus, racial differences may play an important role concerning the association of variants in the dopamine receptor type 1 gene with essential hypertension.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".