Transient Tachypnea of the Newborn May Be an Early Clinical Manifestation of Wheezing Symptoms
Bibliographic record
Abstract
Liem JJ, Huq SI, Ekuma O, Becker AB, Kozyrskyj AL. J Pediatr. 2007;151(1):29–33 PURPOSE OF THE STUDY. To identify risk factors associated with transient tachypnea of the newborn (TTN) and its possible association with wheezing symptoms in early childhood. STUDY POPULATION. Data were collected from the Population Health Research Data Repository at the Manitoba Centre for Health Policy. This was a retrospective evaluation of 12 763 children who were born at term. In this cohort, children with physician-determined bronchiolitis, acute bronchitis, chronic bronchitis, asthma, or need for prescription asthma medications were identified as having wheezing syndromes. METHODS. Children diagnosed with TTN at birth were identified, and Cox proportional hazards regression analysis for time to first event of hospitalization, physician visit, or prescription for an asthma medication up to 7 years of age was performed. Hazard ratios were compared with those of healthy newborns. RESULTS. A total of 308 (2.4%) of the study children developed TTN. Risk factors for development of TTN included maternal asthma, birth weight of ≥4500 g, male gender, and urban location. Infants with TTN at birth had a significantly increased risk of having a wheezing disorder in early childhood (adjusted hazard ratio: 1.17 [95% confidence interval: 1.02–1.34]). CONCLUSIONS. TTN is associated with the development of wheezing syndromes in early childhood. REVIEWER COMMENTS. TTN is generally believed to resolve in 2 to 5 days with no increased risk of pulmonary complications. The findings in this study suggest otherwise, with maternal asthma a risk factor for development of TTN. Nevertheless, the spectrum of wheezing disorders is broad, especially in this study where they evaluated onset of symptoms before 7 years of age, and not every young child with wheezing eventually develops childhood asthma. Additional studies to examine the association between TTN and wheezing before the age of 3 years may help determine if TTN plays a critical role in early pulmonary development.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".