Evidence for the Presence of a Functional TSH-Receptor in Retroocular Fibroblasts from Patients with Graves' Ophthalmopathy
Bibliographic record
Abstract
Konzepte zur Pathogenese des Morbus Basedow müssen sich an der klinischen Trias aus Hyperthy-reose, endokriner Orbitopathie und prätibialem Myxödem orientieren. Der Nachweis eines funktionell bedeutsamen TSH-Rezeptors auf retroorbitalen und prätibialen Fibroblasten könnte die Hypothese eines gemeinsamen Antigens bzw. zellulären Aktivierungsmechanismus von Schilddrüse und extra-thyreoidalen Manifestationen erhärten. Die vorgestellten Studien charakterisieren die funktioneilen Effekte gereinigter G-Immunglobuline mit hoher TSH-Rezeptor-stimulierender Aktivität (TSI) auf zwei im Schilddrüsen-, Retroorbital- und Präti-bialgewebe nachgewiesene Proteine. Die stimulierenden Effekte dieser IgG-Präparationen auf die Expression des 72-kDa-Streßproteins, die Expression des Adhäsionsrezeptors intercellular adhesion molecule-1 (ICAM-1) sowie die ICAM-1-vermittelte Lymphozytenadhäsion sind dosisabhängig, spezifisch für TSI-positive IgGs und selektiv in retroorbitalen Fibroblasten von Patienten mit endokriner Orbitopathie nachweisbar. Unsere Befunde sprechen für die Existenz eines aktivierbaren TSH-Rezeptors im Retroorbitalgewebe, von dessen weiterer funktioneller und immunologischer Charakterisierung Aufschlüsse über seine Rolle in der Pathogenese der Basedow-Trias zu erwarten sind.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".