Application of Click Chemistry in the Preparation of Poly(ethylene oxide)-<i>block</i>-poly(ε-caprolactone) with Hydrolyzable Cross-Links in the Micellar Core
Bibliographic record
Abstract
The aim of this study is to develop degradable core-cross-linked polymeric micelles based on poly(ethylene oxide)- block -poly(ε-caprolactone) (PEO- b -PCL) structures using click chemistry. Substituted monomer, that is, α-propargyl carboxylate-ε-caprolactone, was synthesized by anionic activation of ε-caprolactone and further treatment with propargyl chloroformate. Ring-opening polymerization of α-propargyl carboxylate-ε-caprolactone with methoxy PEO (5000 g/mol) as initiator and stannous octoate as catalyst was used to prepare PEO- b -poly(α-propargyl carboxylate-ε-caprolactone) (PEO- b -PPCL) block copolymer. The block copolymers were found to spontaneously associate in aqueous solution forming well-defined micelles. Stabilization of the micelles was obtained by cross-linking the core via click reaction between the azide group of tetraethylene glycol (bis)azide reagent and the alkyne group on the PPCL block in the presence of copper catalyst at room temperature. Successful cross-linking was evidenced by 1 H NMR, IR spectroscopy, and X-ray photoelectron spectroscopy (XPS). This was followed by the characterization of micellar morphology and size by transmission electron microscopy and light-scattering. Extent of bovine serum albumin (BSA) adsorption for cross-linked and non-cross-linked micelles illustrated the better stability of cross-linked micelles against protein adsorption. Finally, paclitaxel (PTX) was physically encapsulated in the micellar cores, where a similar PTX encapsulation and in vitro release profile for PTX from non-cross-linked and cross-linked micelles was observed. The results pointed to the increased stability of prepared cross-linked micelles and their potential in drug delivery.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".