Executive summary of the Stages of Reproductive Aging Workshop + 10
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Abstract
In Brief Objective The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. Methods Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimüllerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus. Results STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage −3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage −1) and early postmenopause (Stage +1), and recommended application regardless of women’s age, ethnicity, body size, or lifestyle characteristics. Conclusions STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified. STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive and the early postmenopause stages, provided information on the duration of the late transition and early postmenopause, and recommended application regardless of women’s age, ethnicity, body size, or lifestyle characteristics.
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The record
- Venue
- Menopause The Journal of The North American Menopause Society
- Topic
- Menopause: Health Impacts and Treatments
- Field
- Medicine
- Canadian institutions
- Institute of Aging
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentOffice of Research on Women's HealthNational Institute of Child Health and Human DevelopmentNational Institute on Drug AbusePfizerNorthwestern UniversityNational Institute of Mental HealthNational Institute on AgingVirginia Commonwealth UniversityNational Institute of Allergy and Infectious DiseasesServierAmgenNational Institutes of HealthU.S. Department of Health and Human Services
- Keywords
- MedicineAntral follicleContext (archaeology)Ovarian reserveEndocrine systemGynecologyPhysiologyInfertilityHormoneInternal medicinePregnancyBiology
- Has abstract in OpenAlex
- yes