Effects of Pirenzepine on Acute Mucosal Erosions, Gastric Acid and Mucosal Blood Flow in the Spinal Rat Stomach
Bibliographic record
Abstract
The aim of this study was to examine the effects of varying doses of pirenzepine, a selective muscarinic subtype M1 antagonist, on the prevention of acute gastric mucosal lesions in male Sprague-Dawley rats subjected to spinal cord section at the C7 level. It was also intended to evaluate the effects of the drug on gastric acid output and gastric mucosal blood flow. Pirenzepine 1, 2.5 and 5 mg/kg every 2 h all caused a significant reduction in mean total ulcer length (p less than 0.01) compared to controls. This was associated with a significant decrease in acid output (p less than 0.05). There was no significant effect on gastric mucosa blood flow as measured by hydrogen gas clearance. These results indicate that the protective effects of pirenzepine on gastric mucosa, in the spinal rat model, are associated with the acid-inhibitory action of the drug and not on mucosal blood flow effects.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".