Associations of total and abdominal adiposity with risk marker patterns in children at high-risk for cardiovascular disease
Why this work is in the frame
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Bibliographic record
Abstract
BACKGROUND: While body mass index percentiles (BMI%) are commonly used to assess childhood cardiovascular risk, waist circumference percentiles (WC%) are not commonly used nor universally accepted. We tested whether BMI% or WC% should be used to identify risk factor patterns in children at high-risk for developing cardiovascular disease (CVD). A total of 107 children (8-19 years) with cardiovascular risk factors or a family history of CVD were studied. Tobacco exposure, screen-time, blood pressure and anthropometric measures were made, as well as serum risk markers. Principal component analysis (PCA) was used to identify patterns explaining risk factor variance. Multiple linear regression was used to test for associations between risk factor patterns, BMI% and WC%. RESULTS: An adverse lipid pattern (low HDL, high triglycerides and LDL), a pro-inflammatory pattern (high ICAM and TNFαR2), a high blood pressure pattern (high SBP and DBP) and a high Lp(a) pattern were identified. Higher BMI% and WC% were associated with significantly higher levels of the lipid pattern (p < 0.05). BMI% explained 20% of variance in this pattern, whereas WC% explained 22%. When both BMI% and WC% were used together, neither BMI% nor WC% were significantly associated with the lipid pattern. However, BMI% was significantly associated with lower levels of the pro-inflammatory pattern, and WC% was associated higher levels of the pro-inflammatory pattern - together explaining 12% of variance. CONCLUSION: In children at high-risk for CVD, BMI% or WC% explained similar variance in an adverse lipid pattern; however, the combination of BMI% and WC% explained greater variance in a pro-inflammatory pattern than either alone. Both WC% and BMI% should both be used in anthropometric assessments of high-risk children.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it