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Record W2065251926 · doi:10.1139/v04-152

The 2-oxo-3,3,5,5-tetramethylcyclopentanecarboxylic acid ketoenol system in aqueous solution Generation of the enol by flash photolytic Wolff rearrangement of 2-diazo-4,4,6,6-tetramethylcyclohexane-1,3-dione followed by hydration of the acylketene thus formed

2005· article· en· W2065251926 on OpenAlexfundvenueno aff
Y. Chiang, A. J. Kresge, Valerij A. Nikolaev, Ikenna Onyido, Xiaobao Zeng

Bibliographic record

VenueCanadian Journal of Chemistry · 2005
Typearticle
Languageen
FieldChemistry
TopicChemical synthesis and pharmacological studies
Canadian institutionsnot available
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsKeto–enol tautomerismChemistryEnolKeteneWolff rearrangementDiazoFlash photolysisAqueous solutionPhotochemistryTautomerReaction rate constantMedicinal chemistryOrganic chemistryCatalysisKinetics

Abstract

fetched live from OpenAlex

Flash photolysis of 2-diazo-4,4,6,6-tetramethylcyclohexane-1,3-dione in aqueous solution produced 2-oxo-3,3,5,5-tetramethylcyclopentylideneketene, which underwent hydration to the enol of 2-oxo-3,3,5,5-tetramethylcyclo pentanecarboxylic acid; the enol then isomerized to the keto form of the acid. Rates of hydration of the ketene and rates of ketonization of the enol were measured in perchloric acid, sodium hydroxide, and buffer solutions, and rate profiles were constructed. Rates of enolization of 2-oxo-3,3,5,5-tetramethylcyclopentanecarboyxlic acid were also measured, using bromine to scavenge the enol as it formed, and rates of enolization and ketonization were then combined to give the keto–enol equilibrium constant pK E = 1.65. This and other results are discussed in comparison with the behavior of the unmethylated 2-oxocyclopentanecarboxylic acid system.Key words: flash photolysis, photo-Wolff reaction, ketene hydration, enolization, ketonization, keto–enol equilibria, β-oxocarboxylic acids.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.648

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.209
Teacher spread0.197 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2005
Admission routes2
Has abstractyes

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