EGF Receptor Transactivation in Angiotensin II and Endothelin Control of Vascular Protein Synthesis in vivo
Bibliographic record
Abstract
Endothelin represents a necessary intermediate of angiotensin II-induced resistance artery remodeling in hypertension. Recent data suggest that epidermal growth factor receptors are rapidly transactivated by angiotensin II stimulation to mediate its growth-promoting effects. Because endothelin also transactivates epidermal growth factor receptors in vitro, we studied the contribution of epidermal growth factor receptor transactivation in the in vivo trophic actions of the upstream effector angiotensin II and its downstream mediator endothelin in rat mesenteric arteries. Twenty-six-hour infusion of angiotensin II (400 ng/kg per min) or endothelin (5 pmol/kg per min) via osmotic pumps significantly enhanced vascular protein synthesis. With angiotensin II, treatment with the inhibitor of epidermal growth factor receptor transactivation (AG1478, 0.5 mg/kg) produced a significant attenuation (P < 0.05) of protein synthesis. In contrast, AG1478 did not abrogate the elevation of protein synthesis induced by endothelin. In conclusion, angiotensin II-induced epidermal growth factor receptor transactivation seems to be involved in the recruitment of endothelin in the cascade leading to vascular protein synthesis, rather than in the effect of endothelin on small artery remodeling.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".