Evidence of a Physiological Role for Bombesin in the Postnatal Development of the Rabbit Pancreas
Bibliographic record
Abstract
The effect of chronic administration of bombesin (BBN) on the development of the pancreas and the role of endogenous BBN in the postnatal development of exocrine pancreatic function were investigated in suckling New Zealand White rabbits. BBN administered intraperitoneally (i.p) at various doses (1.25, 12.5 and 30 micrograms/kg body weight) to suckling rabbits for 13 days starting on day 4 of life induced pancreatic growth as characterized by dose-dependent increases in pancreatic wet weight, total protein content and total DNA content compared to littermate controls. The maximum effect was observed using bombesin at 30 micrograms/kg. This increase represented hyperplasia since there was no BBN-induced change in the protein:DNA ratio. Pancreatic amylase activity was significantly increased by all doses of BBN, with a maximal effect at 1.25 micrograms/kg. The specific BBN receptor antagonist [Leu13-psi(CH2NH)Leu14]-BBN, given i.p for 9 days at 30 micrograms/kg body weight starting on day 20 of life, significantly reduced the development of pancreatic amylase and lipase activities compared to controls (48 and 36% reductions, respectively). Our findings confirm the trophic effect of BBN on the neonatal pancreas and provide evidence of a physiological role for endogenous BBN-peptides in the development of pancreatic exocrine function.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".