In myasthenia gravis cells from atrophic thymus secrete acetylcholine receptor antibodies
Bibliographic record
Abstract
In generalized MG (GMG), 90% of patients have circulating acetylcholine receptor antibodies (AChRAb) and 80% have abnormal thymic pathology, either lymphoid follicular hyperplasia (LFH) or thymoma.1,2⇓ Whereas thymectomy for patients with thymoma is indicated, the need for surgery in the presence of atrophic thymus or LFH is hotly debated and will be the object of a therapeutic trial. We report that a proportion of patients with atrophic thymus secrete AChRAb in culture and thus might benefit from removal of the immunologically active gland. ### Patients. All patients with GMG underwent transsternal thymectomy after a series of plasmapheresis at University of British Columbia–affiliated hospitals from April 1990 to April 1999. This article reports on the 16 patients who had a pathologic diagnosis of atrophic thymus. Diagnosis was made after review of an average of 6.9 ± 3.4 slides by a single pathologist unaware of the …
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".