Bivariate models for co‐aggregation of dichotomous traits in twins
Bibliographic record
Abstract
The study of twins is widely used for research into genetic and environmental influences on human traits. Study designs in which independent samples of monozygotic and dizygotic twins are compared with respect to their similarity have focused on single binary trait. However, the risk of co-occurrence of more than one disease in twins is a parameter of interest to genetic epidemiologists and other investigators. For example, they may be interested in assessing the genetic and environmental etiologies of reading deficits (RD) and attention deficit hyperactivity disorder (ADHD) and their co-morbidity. In this paper, we present statistical methodology for the estimation of twin similarity with respect to two dichotomous traits measured on each member of the twin pair. For two sample problems, several test procedures that account for the correlation between twins and the correlation between traits are presented. An example based on the Australian population-based twin registry published data is given to illustrate the methodology.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.041 | 0.077 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.004 | 0.004 |
| Bibliometrics | 0.004 | 0.005 |
| Science and technology studies | 0.001 | 0.003 |
| Scholarly communication | 0.004 | 0.003 |
| Open science | 0.006 | 0.005 |
| Research integrity | 0.003 | 0.005 |
| Insufficient payload (model declined to judge) | 0.010 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".