Crohnʼs Disease and the Footprints of Flagellin: Etiopathogenic Clue or Epiphenomenon?
Bibliographic record
Abstract
Elevated flagellin-specific immunoglobulins in Crohn's disease. Sitaraman SV, Klapproth J-M, Moore DA III, et al. Am J Physiol Gastrointest Liver Physiol. 2005;288:G403-406. Inflammatory bowel disease is believed to result from an aberrant mucosal immune response to commensal bacteria that reside in the intestinal tract. In this article, Sitaraman et al hypothesize that flagellin is a specific and dominant immunogenic target of the adaptive mucosal immune system that may be of etiologic importance in Crohn's disease (CD). To test this theory, sera from patients with inflammatory bowel disease and healthy controls were screened for immunoreactivity to lysates of E. coli and Salmonella that had been subjected to SDS-PAGE. Similarly, immunoreactivity to purified flagellin was assessed. Patients with CD were found to have circulating antibodies against a variety of proteins present in the bacterial lysates, but the dominant antigenic target was clearly a band that comigrated with purified flagellin. This was not observed in sera from healthy control patients or in those with ulcerative colitis (UC).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".