Cellular Distribution of Bcl-2 Family Proteins
Why this work is in the frame
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Bibliographic record
Abstract
Proteins synthesized in the cytosol can be inserted into or across organellar membranes depending on the signals present in their primary sequences. Proteins of the Bcl-2 family, which includes proteins that promote programmed cell death (apoptosis) and proteins that inhibit apoptosis, have signals that can target particular members to either the mitochondria or the endoplasmic reticulum (ER) or both. Germain and Shore discuss evidence for a role for the anti-apoptotic members of the family at the ER and describe an interaction with the FK506 binding protein, FKBP38, that may regulate the relative distribution of Bcl-2 proteins at the ER or mitochondria. This interaction may control the cell's sensitivity to apoptotic stimuli.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it