ACETYLCHOLINESTERASE INHIBITION AUGMENTS THE SYMPATHETIC NEURAL RESPONSE TO POSTURAL STRESS
Bibliographic record
Abstract
Muscle sympathetic nerve activity characteristics of burst frequency, mean burst amplitude and total amplitude were assessed during graded head-up tilt (HUT) (5 min each at 0, 20, 40 and 60°) before and 60 min following either an oral dose of pyridostigmine (60 mg; n = 9) or placebo (n = 5). No drug side effects were noticed. Burst frequency and total amplitude increased during HUT for both groups in both conditions. For the placebo group the increases in burst frequency, mean burst amplitude and total amplitude were not different in the repeated trials. However, following pyridostigmine burst frequency was elevated at rest (P < 0.05) and this elevation was sustained during HUT (main effect; P < 0.003). Similarly, mean burst amplitude (P < 0.004) and total amplitude (P < 0.0001) were elevated following pyridostigmine (main effects of drug). No differences in the neural response to a cold pressor test were observed following the drug or placebo treatment. It was concluded that pyridostigmine treatment, at doses that do not produce cholinergic side effects, augmented the sympathetic postganglionic nerve response to orthostatic stress. (Supported by CSA, NSERC, NAG 9-1844 from NASA, R01 AG12227 and M01 RR10732 from NIH).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".