ANTENATAL GLUCOCORTICOIDS: IS THERE CAUSE FOR CONCERN?
Bibliographic record
Abstract
Antenatal glucocorticoid therapy was pioneered by Liggins & Howie over three decades ago. In a controlled trial of babies delivering before 32 weeks gestation, it was shown that antenatal glucocorticoid treatment reduced the incidence of respiratory distress syndrome (RDS) and significantly lowered neonatal mortality. Synthetic glucocorticoid (sGC) therapy is also associated with reduced risk of neonatal intraventricular haemorrhage, necrotizing entercolitis and hyperbilirubinaemia. The benefit of antenatal glucocorticoid therapy to lung function in the newborn infant has led to routine use in situations of threatened pre-term labour. In 1994, a National Institute of Health Consensus Development Conference recommended antenatal treatment of all women at risk of preterm delivery, between 24 and 34 weeks of gestation, with sGC. Similar statements were issued in Europe, Canada and Australia. However, the NIH Consensus Report highlighted the requirement for further research into the long-term effects of antenatal sGC treatment on development of the brain and other organ systems, and their function after birth.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.031 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.003 | 0.004 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.011 | 0.008 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".