ANTENATAL GLUCOCORTICOIDS: IS THERE CAUSE FOR CONCERN?
Bibliographic record
Abstract
Antenatal glucocorticoid therapy was pioneered by Liggins & Howie over three decades ago. In a controlled trial of babies delivering before 32 weeks gestation, it was shown that antenatal glucocorticoid treatment reduced the incidence of respiratory distress syndrome (RDS) and significantly lowered neonatal mortality. Synthetic glucocorticoid (sGC) therapy is also associated with reduced risk of neonatal intraventricular haemorrhage, necrotizing entercolitis and hyperbilirubinaemia. The benefit of antenatal glucocorticoid therapy to lung function in the newborn infant has led to routine use in situations of threatened pre-term labour. In 1994, a National Institute of Health Consensus Development Conference recommended antenatal treatment of all women at risk of preterm delivery, between 24 and 34 weeks of gestation, with sGC. Similar statements were issued in Europe, Canada and Australia. However, the NIH Consensus Report highlighted the requirement for further research into the long-term effects of antenatal sGC treatment on development of the brain and other organ systems, and their function after birth.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".