Functional common gamma chain is not required for mast cell proliferation and survival
Bibliographic record
Abstract
IL-15 is involved in the development and homeostasis of CD8 lymphocytes, NK and iNKT cells, and intraepithelial lymphocytes. It also promotes migration, proliferation and survival of mast cells. Its receptor on lymphocytes is a heterotrimeric complex which shares the IL2-Rβ and common gamma ( γ c ) chains. IL-15-mediated signaling in mast cells might make use of an alternative receptor provisionally designated as IL-15RX. In a murine model, γ c -dependent signaling was shown to be essential for IL-4– and IL-9–induced proliferation and survival of mast cells, but not IL-15 even in the wild-type mouse. Skin biopsies of BCGitis lesions from 6 X-SCID patients were reviewed. Immunostaining using anti-CD117 ( 1/400, DAKO lab ) and tryptase ( 1/400, DAKO lab ) antibodies was performed. A similar BCGitis lesion from a patient with RAG SCID was tested with the same 2 antibodies as controls. Mast cells were present in the skin biopsies of all patients presenting with X-SCID ; their number was not decreased compared to normal skin biopsies. The number of mast cells in the skin biopsy of the RAG SCID patient was also normal. These results suggest that, in humans, γ c is not required for mast cell proliferation and survival. Its impact on IL-15-dependent migration and the possible role of IL-15RX warrant further studies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".