Effects of Tumor Necrosis Factor on Glomerular Mesangial and Epithelial Cells in Culture
Bibliographic record
Abstract
We have previously documented the importance of tumor necrosis factor (TNF) alpha in the pathogenesis of nephrotoxic-serum nephritis in rats. In this study, we evaluated the possible relevance of the well-established cytocidal TNF activity to the mechanism of glomerular injury by assessing sensitivity of rat mesangial and epithelial cell populations to recombinant murine TNF alpha (rMuTNF). Radiolabelled confluent mesangial cell cultures that were incubated with rMuTNF released significantly more 3H-thymidine than control monolayers (maximum specific release was 11.4 +/- 4.9% at 1,000 pg/ml of rMuTNF). rMuTNF was, however, approximately 1,000-fold less cytolytic in mesangial cells than in the lymphotoxin-sensitive L929 cell line. Conversely, glomerular epithelial cells were not affected by exposure to rMuTNF under the same conditions. These results suggest that the cytolytic effect of TNF may contribute to glomerular injury in nephrotoxic-serum nephritis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.003 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".