Fasting triglyceridemia influences postprandial endothelial response to a single Mediterranean-type meal compared to a high-saturated fat meal
Bibliographic record
Abstract
Endothelial dysfunction is considered a precursor of atherosclerosis and is an independent predictor of cardiovascular events. A high-saturated fat meal (HSFAM) has been shown to induce postprandial endothelial dysfunction. However, no studies have evaluated the acute endothelial effect of a single mixed Mediterranean-type meal (MMM). Our objective was to evaluate postprandial endothelial and metabolic function in response to a MMM in comparison to an isocaloric HSFAM and explore the role of baseline triglyceridemia. In this crossover study, 28 healthy non-smoking males were randomly assigned two isocaloric meals on two separate mornings. The MMM, consisting of salmon, almonds and vegetables baked in olive oil, provided 51% of total calories from fat (7.87g SFA and 2.29g of omega-3) while the HSFAM, consisting of sausage, egg and cheese sandwich and fried potatoes, provided 58% of total energy from fat (14.78g SFA). Endothelial function was evaluated by brachial artery flow-mediated dilation (FMD) after a 12-hour fast (T0) and four hours after consumption of the meals. Fasting and postprandial plasma fatty acid profiles were also evaluated. Postprandial FMD was significantly reduced by the HSFAM (-2.5±3.6%, p=0.004), while it was not influenced by the MMM (-1.21±4.6%, ns). Postprandial insulin, AUC TG, TG/HDL and C/HDL were increased to a greater degree in response to the HSFAM. Plasma enrichment in omega-3 PUFA (EPA, DPA and DHA) at the expanse of SFA (18:0) was observed following the MMM. Furthermore, postprandial FMD was significantly reduced by the HSFAM only among individuals with fasting TG levels above the group median (0.87 mmol/L). A single MMM exerts no deleterious effect on postprandial endothelial function and has a lesser impact on metabolic profile than does a HSFAM. This could be resulting from significant postprandial enrichment in fatty acids with better endothelial properties. Moreover, even slightly elevated but normal fasting triglyceridemia could increase the risk of endothelial injury following a single HSFAM.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".