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Stress-induced relapse to heroin and cocaine seeking in rats: a review

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
MetaresearchSystematic reviewNot applicable
Classifier consensus
N/A
Teacher imitation scores

Codex

Other design0.834
Metaresearch0.115
Systematic review0.051
Bench or experimental0.013
Not applicable0.012
Research integrity0.002
Meta-epidemiology (broad)0.001
Theoretical or conceptual0.001
Observational0.001
Scholarly communication0.001
Bibliometrics0.000
Open science0.000
Meta-analysis0.000
Case report0.000
Meta-epidemiology (narrow)0.000
Science and technology studies0.000
Non-randomized trial0.000
Qualitative0.000
Randomized trial0.000
Simulation or modelling0.000

Gemma

Not applicable0.919
Systematic review0.161
Metaresearch0.016
Research integrity0.006
Bench or experimental0.006
Observational0.001
Bibliometrics0.000
Meta-epidemiology (broad)0.000
Science and technology studies0.000
Case report0.000
Meta-analysis0.000
Theoretical or conceptual0.000
Scholarly communication0.000
Open science0.000
Meta-epidemiology (narrow)0.000
Non-randomized trial0.000
Qualitative0.000
Randomized trial0.000
Simulation or modelling0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.340
GPT teacher head0.495
Teacher spread
0.155 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Studies in humans suggest that exposure to stress increases the probability of relapse to drug use, but until recently there has been no animal model to study the mechanisms that mediate this effect. We have developed a reinstatement procedure that allows us to study the effect of stress on relapse to drug seeking in rats. Using this procedure, we have shown that exposure to intermittent footshock stress reliably reinstates heroin and cocaine seeking after prolonged drug-free periods. In the pre…

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