Automatic segmentation of white matter hyperintensities in the elderly using FLAIR images at 3T
Bibliographic record
Abstract
PURPOSE: To determine the precision and accuracy of an automated method for segmenting white matter hyperintensities (WMH) on fast fluid-attenuated inversion-recovery (FLAIR) images in elderly brains at 3T. MATERIALS AND METHODS: FLAIR images from 18 individuals (60-82 years, 9 females) with WMH burdens ranging from 1-80 cm(3) were used. The protocol included the removal of clearly hyperintense voxels; two-class fuzzy C-means clustering (FCM); and thresholding to segment probable WMH. Two false-positive minimization (FPM) methods using white matter templates were tested. Precision was assessed by adding synthetic hyperintense voxels to brain slices. Accuracy was validated by comparing automatic and manual segmentations. Whole-brain, voxel-wise metrics of similarity, under- and overestimation were used to evaluate both precision and accuracy. RESULTS: Precision was high, as the lowest accuracy in the synthetic datasets was 93%. Both FPM strategies successfully improved overall accuracy. Whole-brain accuracy for the FCM segmentation alone ranged from 45%-81%, which improved to 75%-85% using the FPM strategies. CONCLUSION: The method was accurate across the range of WMH burden typically seen in the elderly. Accuracy levels achieved or exceeded those of other approaches using multispectral and/or more sophisticated pattern recognition methods.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.007 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".