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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Momoko Horikoshi, Hanieh Yaghootkar, Dennis O. Mook‐Kanamori, Ulla Sovio, H. Rob Taal, Branwen J. Hennig, Jonathan P. Bradfield, Beaté St Pourcain, David M. Evans, Pimphen Charoen, Marika Kaakinen, Diana L. Cousminer, Terho Lehtimäki, Eskil Kreiner‐Møller, Nicole M. Warrington, Mariona Bustamante, Bjarke Feenstra, Diane J. Berry, Elisabeth Thiering, Thiemo Pfab, Sheila J. Barton, Beverley M. Shields, Marjan Kerkhof, Anthony J. Fulford, Zoltán Kutalik, Wei Zhao, Marcel den Hoed, Anubha Mahajan, Virpi Lindi, Liang-Kee Goh, Jouke‐Jan Hottenga, Ying Wu, Olli T. Raitakari, Marie Neergaard Harder, Aline Meirhaeghe, Ιωάννα Ντάλλα, Rany M. Salem, Anthony James, Kaixin Zhou, Dorota Monies, Vasiliki Lagou, Mirna Kirin, Jani Heikkinen, Linda S. Adair, Fowzan S. Alkuraya, Ali Al‐Odaib, Philippe Amouyel, Ehm A. Andersson, Amanda J. Bennett, Alexandra I. F. Blakemore, Jessica L. Buxton, Jean Dallongeville, Shikta Das, Eco J. C. de Geus, Xavier Estivill, Claudia Flexeder, Philippe Froguel, Frank Geller, Keith M. Godfrey, Frédèric Gottrand, Christopher J. Groves, Torben Hansen, Joel N. Hirschhorn, Albert Hofman, Mads V. Hollegaard, David M. Hougaard, Elina Hyppönen, Hazel Inskip, Aaron Isaacs, Torben Jørgensen, Christina Kanaka‐Gantenbein, John P. Kemp, Wieland Kieß, Tuomas O. Kilpeläinen, Norman Klopp, Bridget Knight, Christopher W. Kuzawa, George McMahon, John P. Newnham, Harri Niinikoski, Ben A. Oostra, Dirkje S. Postma, Susan M. Ring, Fernando Rivadeneira, Neil R. Robertson, Sylvain Sebért, Olli Simell, Torsten Slowinski, Carla M. T. Tiesler, Anke Tönjes, Allan Vaag, Jorma Viikari, Jacqueline M. Vink, Nadja Hawwa Vissing, Nicholas J. Wareham, Gonneke Willemsen, Daniel R. Witte, Haitao Zhang, Jianhua Zhao
Bibliographic record
VenueNature Genetics · 2012
Typearticle
Languageen
FieldMedicine
TopicBirth, Development, and Health
Canadian institutionsnot available
FundersNational Institute of Child Health and Human DevelopmentNational Institute of Environmental Health SciencesNational Institute of Allergy and Infectious DiseasesNational Human Genome Research InstituteNational Heart, Lung, and Blood InstituteBiomedical Research CouncilStrategic Research CouncilEuropean Regional Development FundInstituto de Salud Carlos IIINational Center for Research ResourcesCenters for Disease Control and PreventionFogarty International CenterNational Institutes of HealthNorwegian Biodiversity Information CentreVersus ArthritisU.S. Public Health ServiceNovo Nordisk Foundation Center for Basic Metabolic ResearchH. Lundbeck A/SUniversity of BristolEgmont FondenNational Institute of Diabetes and Digestive and Kidney DiseasesTurun Yliopistollinen KeskussairaalaChinese Society of Clinical OncologyNational Institute of Mental HealthDanmarks GrundforskningsfondSyddansk UniversitetAugustinus FondenEmil Aaltosen SäätiöPaavo Nurmen SäätiöCentre for Medical Systems BiologyNovo NordiskJuho Vainion SäätiöLundbeckfondenGeneralitat de CatalunyaGeneralitat ValencianaDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekTurun YliopistosäätiöErasmus Medisch CentrumVrije Universiteit AmsterdamErasmus Universiteit RotterdamZonMwMünchner Zentrum für GesundheitswissenschaftenCurtin University of TechnologyNational Health and Medical Research CouncilOulun YliopistoSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Science FoundationBoehringer Ingelheim FondsRaine Medical Research FoundationSundhed og Sygdom, Det Frie ForskningsrådMinisterio de Ciencia e InnovaciónEuropean CommissionBiocenter, University of OuluNational Research FoundationNational Institute for Health and Care ResearchCanadian Institutes of Health ResearchDiabetes UKUniversity of SouthamptonCancer Research UKWellcome TrustBritish Heart FoundationWomen and Infants Research FoundationChildren's Hospital of PhiladelphiaMedical Research CouncilFundació la Marató de TV3Yrjö Jahnssonin SäätiöJuvenile Diabetes Research Foundation InternationalMarch of Dimes FoundationTampereen TuberkuloosisäätiöUniversität PotsdamEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentGlaxoSmithKlineScottish Government
KeywordsBiologyGenome-wide association studyGeneticsBirth weightType 2 diabetesGenetic associationPhenotypeDiabetes mellitusPhysiologyGeneSingle-nucleotide polymorphismPregnancyEndocrinologyGenotype
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.013
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.010
GPT teacher head0.267
Teacher spread0.257 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations320
Published2012
Admission routes1
Has abstractno