Bibliographic record
Abstract
Two amide penicillins, 2-[(3,3-dimethyl-7-oxo-6-[2-phenylacetamido]-4-thia-1-azabicyclo[3.2.0]hept-2-yl)carbonyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (Wy-12,556) and 2-[2,3-dimethyl-7-oxo-6(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-ylcarbonyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide, hydrate (Wy-12,405), were compared with benzathine penicillin G for their duration of therapeutic activity in mice; potassium penicillin G and potassium penicillin V were also included in this study. In animals primed with these agents the amide penicillins were significantly more active than benzathine penicillin G with respect to dosage. Wy-12,405 reached its peak of effectiveness in animals treated 4 days prior to infection. Wy-12,556 was two times more effective than Wy-12,405 in mice treated 8, 12 and 16 days prior to challenge. Although the potency ratios of the amide penicillins declined gradually after the 8th day, both continued to be more effective than benzathine penicillin G. When the treated mice were challenged with progressively larger numbers of bacterial cells Wy-12,556 proved to be more effective than benzathine penicillin G in combating the infection.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".