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The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

2007· article· en· 851 citations· W2070224555 on OpenAlex· 10.1038/ncb1537

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.006
GPT teacher head0.257
Teacher spread
0.251 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Cell Biology
Topic
Cancer-related Molecular Pathways
Field
Medicine
Canadian institutions
University of Toronto
Funders
National Institute of Environmental Health SciencesEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Cancer Institute
Keywords
AutophagyAMPKCell biologyProtein kinase APhosphorylationAMP-activated protein kinaseApoptosisNutrient sensingCell growthKinaseSignal transductionChemistryGene knockdownBiologyBiochemistry
Has abstract in OpenAlex
no