Follicular Dendritic Cell Sarcoma Arising in Hyaline-Vascular Castleman Disease of Mediastinum: A Case Report
Bibliographic record
Abstract
Follicular dendritic cell (FDC) sarcoma is a rare neoplasm that is grouped as histiocytic and dendritic cell neoplasm. It can occur primarily in lymph nodes but also in extranodal sites. Follicular dendritic cells are nonlymphoid, nonphagocytic accessory cell in the immune system. Their dendritic cell nature can be demonstrated by the various FDC markers, such as CD21, CD23, CD35, R4/23, and Ki-4p. FDC sarcoma may occur in association with Castleman disease in 10 - 20% cases. We experienced a case of FDC sarcoma associated with hyaline vascular type-Castleman disease (HVCD). A 62-year-old woman presented a posterior mediastinal mass shown by computed tomography. The resected mass was an encapsulated solid mass, measuring 5.5 x 4 cm in size. Microscopically, the tumor was composed of spindle cells showing a fascicular and storiform arrangement. There are some areas reminiscent of HVCD. The tumor cells were positive for the FDC marker CD21. doi:10.4021/jmc215w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".