Utilidad de las formulaciones Vimang® en pacientes con osteoartrosis de rodilla
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Bibliographic record
Abstract
La osteoartrosis (OA) es la forma más común de artropatía y su localización en la articulación de la rodilla tiene una gran frecuencia. Dentro del grupo de fármacos de acción lenta para su tratamiento se aceptan los antioxidantes por su efecto protector en la progresión de la enfermedad. El Vimang® es una marca comercial registrada que cubre varios tipos de formulaciones a partir del extracto de la corteza del árbol de mango con propiedades antioxidantes, analgésicas, antiinflamatorias e inmunomoduladoras. El objetivo del presente estudio fue determinar la actividad analgésica de las tabletas y crema Vimang® en pacientes portadores de OA de rodilla y la posible mejoría de la capacidad funcional postratamiento. De igual manera, caracterizar mediante ultrasonografía los efectos del Vimang® en la inflamación sinovial (efusión y proliferación) que se asocia a la entidad. Se estudiaron 10 pacientes del Hogar Santovenia con diagnóstico clínico-de imagen de OA de rodilla. Sus puntuaciones diarias medias de dolor estaban comprendidas entre 4 o superiores la semana previa al inicio del tratamiento, según una escala de Likert de 11 puntos. Se aplicó el índice de capacidad funcional de WOMAC (The Westerm Ontario and Mc Master Universities Osteoarthritis Index) en la consulta inicial y al concluir el estudio. De igual manera, se realizó ultrasonido de partes blandas de ambas rodillas (equipo ALOKA 1100 con transductor de 7,5 mHz). Los pacientes fueron asignados aleatoriamente a 3 grupos (grupo Vimang tabletas 900 mg/día [n = 4], grupo Vimang tabletas 1.800 mg/día [n = 3] y grupo Vimang tabletas 900 mg/día + crema Vimang 1,2% [n = 3]). La administración de las tabletas se repartió en 3 tomas cada 8 h y la crema se aplicó 3 veces al día con el mismo intervalo en la rodilla afectada. La extensión del tratamiento en este estudio fue de 3 meses. Todos los pacientes mostraron analgesia satisfactoria a partir de los 15-21 días hasta los 3 meses. Este efecto se relaciona, al menos en parte, con la disminución de la efusión sinovial que se observó en la mayoría de las articulaciones afectadas, pero fue independiente de la disminución del grosor de la sinovial constatada por ultrasonografía. Se observaron ambos efectos, promoción e inhibición de la proliferación sinovial, independientemente de la analgesia. La inhibición de la proliferación de la membrana sinovial con respecto a los valores iniciales sólo fue significativa en el grupo Vimang 900. Los 10 pacientes mejoraron su calidad de vida en relación con el alivio del dolor y el aumento de la capacidad funcional según el índice de WOMAC. Osteoarthrosis (OA) is the most common form of arthritis and localization in the knee is common. Symptomatic slow acting drugs for osteoarthritis include antioxidant agents as possible modifiers of disease progression. Vimang’ is a registered brand name that covers several formulations of Mangifera indica L., used for its antioxidant, antiinflammatory, analgesic and immunomodulatory properties. The aim of the present study was to determine the analgesic activity of Vimang tablets and cream in patients with knee OA and identify possible posttreatment functional improvement. A further aim was to characterize the effects of Vimang on the synovial inflammation (effusion and proliferation) associated with this entity using ultrasonography. Ten patients from Hogar Santovenia with a clinical-radiological diagnosis of knee OA were studied. Mean daily pain scores on an 11-point Likert scale were 4 or higher in the week prior to treatment initiation. The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index was evaluated in the initial consultation and at the end of the study. Ultrasonographic examination (ALOKA device 1100 with a 7.5 mHz transducer) of the soft tissue of both knees was performed. The patients were randomly assigned to three groups. Group 1 (n = 3) received a daily dose of 1,800 mg/day (tablets), group 2 (n = 4) received 900 mg/day (tablets) and group 3 (n = 3) received a combination of tablets 900 mg/day and Vimang cream 1.2%. The tables were administered in three daily doses every 8 hours and the cream was applied three times per day every 8 hours on the affected knee. Treatment duration was 3 months. Satisfactory analgesia was achieved in all patients from days 15-21 until 3 months. This effect was at least partly related to the decrease in synovial effusion observed in most affected joints and was independent of the reduction in synovial thickness observed on ultrasound. Both effects, the increase and decrease in synovial thickness, were independent of the analgesia. The inhibition of synovial membrane proliferation compared with initial values was significant only in group 2. Quality of life improved in all patients, due to pain relief and the increase in functional capacity as measured by the WOMAC index.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it